Heart failure & cardiomyopathies
Efficacy of sinus rhythm maintenance after catheter ablation for atrial fibrillation in patients with transthyretin amyloid cardiomyopathy
Main finding · Composite of HF hospitalization, ischemic stroke and all-cause mortalityResult — go to the resultHazard ratio 0.25 95% CI 0.11–0.62Authors' conclusion
AF ablation appears to be an effective strategy especially for stage I amyloidosis, with maintenance of sinus rhythm associated with better clinical outcomes.
Study context
- Population
- Patients with ATTR-CM and atrial fibrillation (AF), 7 institutions
- Participants
- 149 patients7 institutions
- Exposure
- Catheter ablation vs no ablation for AF
- Ablationn = 53
- Outcome
- Composite of:
- HF hospitalization
- Ischemic stroke
- All-cause mortality
Methodological detailsmulticentre, matched
- Multicentre
- Matched
Main finding
As reported in the abstract
Hazard ratio
0.25
95% CI 0.11–0.62
P = 0.003
Ablationvs No-ablation
HR 0.25 (95% CI 0.11–0.62); P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Composite end points by ATA recurrence after initial ablation (ablation group)No ATA recurrencevs ATA recurrence | 0.17 (0.03–0.82) | P = 0.02 | |
| 0.050.21520Hazard ratio (log scale) |
Atrial tachyarrhythmia (ATA) recurrence and clinical outcomes by ATTR-CM stage (ablation group)
- Stage I had fewer ATA recurrences and better clinical outcomes
Original publication
Efficacy of sinus rhythm maintenance after catheter ablation for atrial fibrillation in patients with transthyretin amyloid cardiomyopathy. Heart Rhythm. Published 17 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →