Efficacy and safety of postoperative autologous blood transfusion in cardiac surgery (RESCUE): Rationale, design, and study protocol of a multicenter randomized controlled trial
Study context
- Population
- Patients undergoing elective on- or off-pump CABG with shed mediastinal blood >500 mL within first 6 hours postoperativelyplanned 1,232
- Planned comparison
- Postoperative autologous blood transfusion (PABT) vs standard care
- Primary endpoint
- Postoperative allogeneic RBC transfusion volume (cumulative, day of surgery to discharge)
Methodological detailsstudy protocol, single-blind, multicentre, Randomised 1:1; 30-day follow-up, Primary safety endpoint: composite of postoperative infections (pneumonia, bloodstream infections, surgical site infections), Recruitment planned January 2026 to December 2029; currently in preparatory phase
- Study protocol
- Single-blind
- Multicentre
- Randomised 1:1; 30-day follow-up
- Primary safety endpoint: composite of postoperative infections (pneumonia, bloodstream infections, surgical site infections)
- Recruitment planned January 2026 to December 2029; currently in preparatory phase
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Efficacy and safety of postoperative autologous blood transfusion in cardiac surgery (RESCUE): Rationale, design, and study protocol of a multicenter randomized controlled trial. Am Heart J. Published 27 November 2025. doi:10.
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