Heart failure & cardiomyopathies
Endogenous Sex Hormone Levels and Myocardial Fibrosis in Men and Postmenopausal Women
Main finding · Myocardial fibrosis per 1-SD increment in sex hormonesResult — go to the resultOdds ratio 4.10 95% CI 1.35–12.40Authors' conclusion
Among older men, SH imbalances at initial evaluation were independently associated with CMR defined IMF and replacement fibrosis, respectively; while increasing total testosterone in middle-aged PMW was associated with lesser marker of IMF.
Study context
- Population
- Men and postmenopausal women in MESA with sex hormones measured at baseline and cardiac magnetic resonance (CMR) 10 years latermen and PMW
- Participants
- 2,324 men
- Exposure
- Baseline sex hormone levels
- Outcome
- Interstitial myocardial fibrosis (ECV% and native T1 time by CMR T1 mapping) and replacement fibrosis (LGE; men only)
- Follow-up
- 10 years later
Methodological detailsMESA cohort, analyses stratified by sex and age
- MESA cohort
- Analyses stratified by sex and age
Main finding
As reported in the abstract
Myocardial fibrosis per 1-SD increment in sex hormones
Odds ratio
4.10
95% CI 1.35–12.40
P = 0.01
Higher estradiol (older men)
OR 4.10 (95% CI 1.35–12.40); P = 0.01
Per 1-SD increment in sex hormones, as printed
- Older men (≥65 y): free testosterone, extracellular volume (ECV)% lower
- 2.45%
- Older men (≥65 y): free testosterone, native T1 time lower
- 21.5%
- Older men (≥65 y): bioavailable testosterone, native T1 time lower
- 12.5%
- Sex hormone-binding globulin, ECV% higher
- 1%
- PMW 55 to 64 y: total testosterone, native T1 time lower
- 9.5%
Observational data: associations, not effects.
Original publication
Endogenous Sex Hormone Levels and Myocardial Fibrosis in Men and Postmenopausal Women. JACC Adv. Published 10 May 2023. doi:10.
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