Epidemiology of Coronary Atherosclerosis Among People Living With HIV in Uganda : A Cross-Sectional Study
Main finding · Prevalence of CAD (calcified or noncalcified plaque on computed tomography)Result — go to the resultAbsolute prevalence difference 2.7% 95% CI −1.6% to 7.0%Authors' conclusion
The prevalence of CAD in Uganda was low compared with population-based cohorts from the Global North with similar CVD risk profiles and was similar between HIV serostatus subgroups. Our results suggest that CAD may not be a major cause of morbidity in Uganda.
Study context
- Population
- Ambulatory people living with HIV (PWH), aged older than 40 years, taking antiretroviral therapy for 3 or more years, and population-based, age- and sex-similar people without HIV (PWoH), Southwestern Ugandaof 630 screened, met criteria and had evaluable images
- Participants
- 586 people
- Exposure
- Presence of coronary atherosclerotic disease (CAD) by HIV serostatus
- PWHn = 287
- PWoHn = 299
- Outcome
- Prevalence of CAD (calcified or noncalcified plaque on computed tomography)
Main finding
As reported in the abstract
Absolute prevalence difference
2.7%
95% CI −1.6% to 7.0%
Events by group
PWHvs PWoH
absolute prevalence difference 2.7% (95% CI −1.6% to 7.0%)
- Overall prevalence of CAD
- 45 of 586 [7.7%]
Observational data: associations, not effects.
Further findings
| Outcome | PWH | PWoH |
|---|---|---|
| Baseline characteristics by HIV serostatus | ||
| Mean age | 57.9 years | 57.4 years |
| Median CVD risk score | 4.1 | 3.4 |
- Baseline characteristics by HIV serostatus — Proportion female
- 49%
- Baseline characteristics by HIV serostatus — PWH virologically suppressed
- 272 of 287 [95%]
Baseline characteristics by HIV serostatus
- Did not differ by HIV serostatus
Original publication
Epidemiology of Coronary Atherosclerosis Among People Living With HIV in Uganda : A Cross-Sectional Study. Ann Intern Med. Published 12 March 2025. doi:10.
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