Heart failure & cardiomyopathies
Evaluation of Recurrent Takotsubo Syndrome
Authors' conclusion
Recurrent TTS episodes occurred in a significant proportion of cases, a median of 3.30 years after the index event. The recurrent episodes often had distinct triggers and different wall motion abnormalities compared to the index event.
Study context
- Population
- TTS survivors, Cedars-Sinai Smidt Heart Institute Takotsubo Registryadjudicated TTS
- Participants
- 88 survivors
- Exposure
- Participants with vs without recurrent TTS
- Recurrencen = 15
- Outcome
- Recurrent TTS events and variables associated with recurrence
Methodological detailsobservational registry, retrospective and prospective data, consecutive participants, Detailed medical records adjudicated; standardised psychosocial questionnaires administered remotely
- Observational registry
- Retrospective and prospective data
- Consecutive participants
- Detailed medical records adjudicated; standardised psychosocial questionnaires administered remotely
Main finding
As reported in the abstract
At least 1 recurrent TTS event
| Group | Value | Time to first recurrent event, median (range) |
|---|---|---|
| Recurrence | 17% | 3.30 years (0.13-18.56 years) |
Recurrence
Value17%
Time to first recurrent event, median (range)3.30 years (0.13-18.56 years)
Observational data: associations, not effects.
Further findings
- Wall motion abnormality pattern across events — Recurrence
- 9 events
Wall motion abnormality pattern across events
- Different wall motion abnormality patterns between events in 9 of 15
Recurrence-free survival by index wall motion pattern
- Recurrence-free survival significantly differed by wall motion pattern at index event
Index-event clinical, ECG, echocardiographic and invasive data
- Similar between participants with and without recurrence
Original publication
Evaluation of Recurrent Takotsubo Syndrome. JACC Adv. Published 17 September 2024. doi:10.
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