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Heart failure & cardiomyopathiesSecondary analysis

Event rates of patients with stable heart failure with reduced ejection fraction and newly diagnosed obstructive or central sleep apnoea

Eur J Heart FailPublished

  • Post-hoc analysis of the ADVENT-HF trial
Read the original article ↗

Authors' conclusion

Detection of CSA in patients with stable HFrEF identifies a population at increased 1-year risk of adverse events who may benefit from earlier evaluation for advanced therapies or transplantation.

Study context

Population
Stable heart failure with reduced ejection fraction (HFrEF) patients with newly diagnosed OSA or CSA
Participants
198 vs 533
Comparison
CSA vs OSA
  • CSAn = 198
  • OSAn = 533reference
Primary endpoint
Primary composite endpoint (PE), all-cause and CV mortality
Follow-up
Over the trial duration

Primary result

As reported in the abstract

CSA vs OSAHazard ratio (95% CI)P value
PE, unadjusted
1.38(1.10–1.73)
P = 0.01
all-cause mortality, unadjusted
1.72(1.26–2.36)
P < 0.001
CV mortality, unadjusted
2.00(1.40–2.85)
P < 0.001

Further findings

All-cause mortality (unadjusted) · over the trial duration

  • not statistically significant after adjustment for clinical characteristics associated with worse prognosis

CV mortality (unadjusted) · over the trial duration

  • not statistically significant after adjustment for clinical characteristics associated with worse prognosis

Adjusted HRs before and after 1 year (HRs varied over time, inflection point at one year)

Primary composite endpoint, adjusted HR before 1 year
1.41 (95%CI 1.00-2.01, P = .051)
Primary composite endpoint, adjusted HR after 1 year
.91 (95%CI .65-1.26, P = .562)
All-cause mortality, adjusted HR before 1 year
3.44 (95%CI 1.61-7.36, P = .001)
All-cause mortality, adjusted HR after 1 year
.89 (95%CI .58-1.37, P = .603)
CV mortality, adjusted HR before 1 year
3.58 (95%CI 1.58-8.12, P = .002)
CV mortality, adjusted HR after 1 year
.92 (95%CI 0.56-1.51, P = 0.741)

Original publication

Event rates of patients with stable heart failure with reduced ejection fraction and newly diagnosed obstructive or central sleep apnoea. Eur J Heart Fail. Published 28 May 2026. doi:10.1093/ejhf/xuag110
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Summarised from the published abstract; every number is checked against it