Heart failure & cardiomyopathies
Exploring Heart Failure Prevalence and Dimensions: A Comprehensive NT-ProBNP Study in High-Risk Primary Care Patients
Authors' conclusion
A significant proportion of high-risk individuals in primary care had undiagnosed HF, particularly Stage B (pre-HF) and early symptomatic Stage C HF. The predominance of HFpEF highlights the need for targeted management. NT-proBNP screening is a valuable tool for early identification and risk stratification, especially for detecting Stage B HF, where it serves as an effective standalone method in the absence of imaging.
Study context
- Population
- Participants aged ≥40 years with at least one heart failure (HF) risk factor but no prior HF diagnosis, in primary care
- Participants
- 874 participants
- Exposure
- Stage A vs Stage B vs Stage C
- Outcome
- Baseline characteristics
Main finding
As reported in the abstract
Mean age
62.5 ± 9.1 years
Female
51.9%
Observational data: associations, not effects.
Further findings
ACC/AHA HF stage distribution
| Outcome | Stage A | Stage B | Stage C |
|---|---|---|---|
| Elevated NT-proBNP levels | — not stated in the abstract | 84.8% | 100% |
— not stated in the abstract
HF with preserved ejection fraction (HFpEF) among Stage C patients
- Among Stage C patients, HF with preserved ejection fraction (HFpEF)
- 92.4%
Correlation of N-terminal probrain natriuretic peptide (NT-proBNP) with echocardiographic and renal measures
- Left atrial volume index
- r = 0.273, P < 0.001
- Left ventricular mass index
- r = 0.207, P < 0.001
- E/e′ ratio
- r = 0.182, P < 0.001
- Estimated systolic pulmonary artery pressure
- r = 0.124, P < 0.001
- Estimated glomerular filtration rate (negative correlation)
- r = −0.222, P < 0.001
Original publication
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