Acute cardiac care & resuscitation
External validation of organ perfusion pressure as a prognostic marker in cardiogenic shock
Authors' conclusion
In this multicenter CS cohort, admission OPP was an independent prognostic marker of in-hospital mortality, irrespective of underlying CS etiology. Its inherent simplicity and demonstrated clinical robustness may support its integration into risk stratification and CS protocols.
Study context
- Population
- Patients admitted for cardiogenic shock related to heart failure or acute myocardial infarction, July 2023 to October 2024patients considered
- Participants
- 621 patients
- Exposure
- Admission organ perfusion pressure (OPP) as a predictor of in-hospital all-cause death
- Nonsurvivorsn = 247
- Outcome
- In-hospital all-cause death
- Follow-up
- In-hospital
Methodological detailsconsecutive patients, external validation
- Consecutive patients
- External validation
Main finding
As reported in the abstract
Estimate (95% CI)P value
Low OPP (<57 mmHg)univariable; consistent across both AMI-CS and HF-CS cohorts
OR 3.20(2.25–4.56)
P < 0.001Lower OPPmultivariable logistic regression
OR per mmHg decrease 1.03(1.01–1.06)
P = 0.020- In-hospital all-cause death
- 247 (39.8%)
Observational data: associations, not effects.
Further findings
Median, mmHg
| Outcome | Nonsurvivors | Survivors | P value |
|---|---|---|---|
| OPP · admissionNonsurvivors vs survivors · significantly lower OPP in nonsurvivors | 59 (IQR 49–69) | 70 (IQR 60–80) | P < 0.001 |
Baseline characteristics
- Mean age
- 62 ± 13 years
- Female
- 138 [22.2%]
- SCAI stage ≥ C severity
- 518 (83.4%)
Model performance of OPP for in-hospital mortality
- C-index
- 0.691
- Slope
- 1.01
- Intercept
- 0.01
Original publication
External validation of organ perfusion pressure as a prognostic marker in cardiogenic shock. Am Heart J. Published 17 April 2026. doi:10.
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