Morphological characteristics of lesions with thin cap fibroatheroma—a substudy from the COMBINE (OCT-FFR) trial
Authors' conclusion
Within TCFA carrying patients, a smaller MLA, lower FFR values, and TCFA location adjacent to a HP were associated with future MACE.
Study context
- Population
- Fractional flow reserve (FFR)-negative diabetes mellitus (DM) patients with ≥1 optical coherence tomography (OCT)-detected thin cap fibroatheroma (TCFA)of 390 FFR-negative DM patients
- Participants
- 98 patients
- Comparison
- TCFA-carrying DM patients with vs without MACE during follow-up
- MACEn = 13
- non-MACEn = 85reference
- Primary endpoint
- OCT qualitative and quantitative variables associated with MACE (cardiac death, target vessel MI, clinically driven target lesion revascularization, hospitalization for unstable angina)
Primary result
As reported in the abstract
Healed plaque prevalence
P = 0.01
| Outcome | MACE | non-MACE | P value |
|---|---|---|---|
| MLA | 1.80 mm² | 2.50 mm² | P = 0.01 |
| Mean FFR | 0.85 | 0.89 | P = 0.02 |
Original publication
Morphological characteristics of lesions with thin cap fibroatheroma—a substudy from the COMBINE (OCT-FFR) trial. Eur Heart J Cardiovasc Imaging. Published 7 November 2022. doi:10.
Summarised from the published abstract; every number is checked against it