Heart failure & cardiomyopathies
Frailty Interferes with the Guideline-Directed Medical Therapy in Heart Failure Patients with Reduced Ejection Fraction
Main finding · Physical frailtyResult — go to the resultOdds ratio 6.900 95% CI 1.420–33.600Authors' conclusion
The results of this study suggest that physical frailty is one of the factors that may withhold GDMT in patients with HFrEF.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF) hospitalized for acute decompensated HF, Japan, 2017–2019assessed for frailty, of 339 HFrEF
- Participants
- 268 patients
- Exposure
- Physical frailty vs physical non-frailty; with guideline-directed medical therapy (GDMT) vs without GDMT
- Outcome
- Association between implementation of GDMT at discharge and physical frailty
- Follow-up
- Discharge
Methodological detailsretrospective analysis of a prospective multicentre observational study (Kochi YOSACOI)
- Retrospective analysis of a prospective multicentre observational study (Kochi YOSACOI)
Main finding
Physical frailty
Odds ratio
6.900
95% CI 1.420–33.600
P = 0.017
By group
Physical frailtyvs Physical non-frailty
OR 6.900 (95% CI 1.420–33.600); P = 0.017
As reported in the abstract
Observational data: associations, not effects.
Further findings
Age
P < 0.001
Prescription by frailty status (frailty vs non-frailty)
- Renin-angiotensin system (RAS) inhibitors only
- 52.0% vs. 86.7%, P < 0.05
- Beta-blockers only
- 70.1% vs. 100.0%, P < 0.05
- Both RAS inhibitors and beta-blockers
- 42.5% vs. 86.7%, P < 0.01
Other characteristics, without vs with GDMT
- More prior HF admission without GDMT
- P = 0.004
- Lower eGFR without GDMT
- P < 0.001
- Higher rate of cognitive impairment without GDMT
- P = 0.009
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Frailty Interferes with the Guideline-Directed Medical Therapy in Heart Failure Patients with Reduced Ejection Fraction. ESC Heart Fail. Published 3 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →