Valvular & structural heart disease
Unlocking prognostic insights in severe tricuspid regurgitation: impact of right ventricular volumes and function by cardiac magnetic resonance
Authors' conclusion
Thresholds of RV volume and function by CMR stratifying low-intermediate and high-risk of cardiovascular events are defined in a multicentre cohort of patients. Compared with low-risk group, high- and, to a lower extent, intermediate-risk groups are independently associated to HF and all-cause mortality.
Study context
- Population
- Patients with at least severe tricuspid regurgitation (TR) (severe, massive, and torrential) assessed by 2D echocardiography undergoing a contemporary cardiac magnetic resonance (CMR) studypatients with severe TR
- Participants
- 314 patients
- Exposure
- Compared with low-risk groups, high-risk and intermediate-risk thresholds of RV end-diastolic volume (RV-EDV) and RV ejection fraction (RVEF)
- Outcome
- combined endpoint of all-cause mortality or hospitalization for heart failure (HF) events
- Follow-up
- Median 35 months (interquartile range: 12-60)
Main finding
As reported in the abstract
Adj HR (CI)P value
RV-EDVadjusted for clinical and imaging variables
1.015(1.012–1.019)
P < 0.001RVEFadjusted for clinical and imaging variables
0.957(0.938–0.976)
P < 0.001RV-EDV > 150 mL/m²vs low-risk groups
5.42(3.20–9.16)
RVEF < 50%vs low-risk groups
2.12(1.21–3.71)
RV-EDV 100-150 mL/m²vs low-risk groups
1.72(1.11–2.64)
RVEF 50-60%vs low-risk groups
1.59(1.04–2.43)
- Patients who experienced the combined endpoint
- 39%
Observational data: associations, not effects.
Original publication
Unlocking prognostic insights in severe tricuspid regurgitation: impact of right ventricular volumes and function by cardiac magnetic resonance. Eur Heart J Cardiovasc Imaging. Published 22 March 2025. doi:10.
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