Valvular & structural heart disease
Sex-specific differences in right heart remodelling and patient outcomes in secondary tricuspid regurgitation
Authors' conclusion
In STR, women face a similar risk at lower EROAs and RegVols, along with smaller RV volumes, higher RVEF, and reduced TA dimensions. These findings highlight the importance of incorporating sex-specific thresholds into clinical decision-making when assessing STR severity and right heart remodelling.
Study context
- Population
- Patients with moderate or severe secondary tricuspid regurgitation (STR)74 ± 13 years, 51% women
- Participants
- 554 patients
- Comparison
- Sex-specific risk-based cut-offs for STR severity and right ventricular (RV) and tricuspid annulus (TA) remodelling, women vs men
- Outcome
- All-cause mortality or heart failure hospitalization
- Follow-up
- Median 19 (8-27) months; event-free survival at 2 years
Methodological detailsinverse propensity weighting
- Inverse propensity weighting
Main finding
As reported in the abstract
Patients reaching the composite endpoint
230
Further findings
Sex-specific risk-based thresholds for STR severity and right heart remodelling
EROA Women 0.36 cm² · Men 0.43 cm²
RegVol Women 31 mL · Men 35 mL
Regurgitant fraction
RV end-diastolic volume Women 81 mL/m² · Men 96 mL/m²
RV end-systolic volume Women 37 mL/m² · Men 49 mL/m²
RVEF
TA diameter Women 19 mm/m² · Men 22 mm/m²
Baseline characteristics
- Women older
- P < 0.001
- Women: higher prevalence of atrial fibrillation
- P = 0.008
- Women: higher prevalence of atrial STR
- P < 0.001
- Men: more coronary artery disease
- P < 0.001
- Men: more chronic kidney disease
- P = 0.005
- Men: more mitral regurgitation
- P < 0.001
- Women: smaller RV and TA dimensions and higher RV ejection fraction (RVEF)
- P < 0.001
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →