Heart failure & cardiomyopathies
Generalizable Approach to Quantifying Guideline-Directed Medical Therapy
Authors' conclusion
KCMO measures GDMT intensity by incorporating dosing and treatment eligibility, provides more granularity than existing methods, is easily interpretable (percentage of ideal GDMT), and can be adapted as performance measures evolve.
Study context
- Population
- Patients with HF; Guideline-directed medical therapy (GDMT) (MRA, β-blocker, ACEi/ARB/ARNI) intensity at baseline and 1-year change4,061 with 1-year change
- Participants
- 4,532 patients
- Comparison
- Kansas City Medical Optimization (KCMO) score vs HF collaboratory and modified HF Collaboratory scores
Primary result
As reported in the abstract
Baseline GDMT intensity score
| Group | Value | Coefficient of variation |
|---|---|---|
| KCMO | mean 38.8 (SD 25.7) | 0.66 |
| HF collaboratory | mean 3.4 (SD 1.7) | 0.49 |
| Modified HF Collaboratory | mean 42.2 (SD 22.2) | 0.53 |
Value
KCMOmean 38.8 (SD 25.7)
HF collaboratorymean 3.4 (SD 1.7)
Modified HF Collaboratorymean 42.2 (SD 22.2)
Coefficient of variation
KCMO0.66
HF collaboratory0.49
Modified HF Collaboratory0.53
Further findings
Mean
| Outcome | KCMO | HF collaboratory | Modified HF Collaboratory |
|---|---|---|---|
| 1-year change in score | −1.94 (SD 17.8) | −0.11 (SD 1.32) | −1.35 (SD 19.8) |
- 1-year change in score: n=4061
Original publication
Generalizable Approach to Quantifying Guideline-Directed Medical Therapy. Circ Heart Fail. Published 14 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →