Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia
Authors' conclusion
Study findings suggest genetic associations of 4 cardiovascular disease-related proteins with gestational hypertension and 2 associated with preeclampsia.
Study context
- Population
- European-ancestry female individuals (HDP GWAS meta-analyses); SCALLOP consortium protein data
- Outcome
- Gestational hypertension and preeclampsia
Methodological detailssystematic review of observational data, phenome-wide mendelian randomization (MR), Protein data: 21 758 participants (SCALLOP); gestational hypertension: 393 238 female individuals (8636 cases, 384 602 controls); preeclampsia: 606 903 (16 032 cases, 590 871 controls)
- Systematic review of observational data
- Phenome-wide MR
- Protein data: 21 758 participants (SCALLOP); gestational hypertension: 393 238 female individuals (8636 cases, 384 602 controls); preeclampsia: 606 903 (16 032 cases, 590 871 controls)
Pooled result
As reported in the abstract
Genetic associations of CVD-related proteins with HDPs
Proteins with ≥1 valid cis-pQTL
75 of 90
83.3%
Proteins significantly associated with HDPs
10
13.3%
Robust for gestational hypertension: CD40, ECP, galectin 3, NT-proBNP
4
Robust for preeclampsia: cystatin B, HSP27
2
Further pooled results
First-trimester protein levels and HDP risk (observational data)
- Lower NT-proBNP vs no HDPs
- 0.76- to 0.88-fold difference
- Higher HSP27 vs no HDPs
- 2.40-fold difference
- Higher ECP vs no HDPs
- 1.60-fold difference
Phenome-wide MR: non-HDP-related protein-disease associations
- Unique non-HDP-related protein-disease associations
- 37
Original publication
Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia. JAMA Cardiol. Published 1 March 2024. doi:10.
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