Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study
Authors' conclusion
Sociodemographic, clinical, and laboratory factors are each associated with CAD recurrence with genetic risk, age at first CAD event, and HDL cholesterol concentration explaining the most.
Study context
- Population
- Middle-aged UK Biobank adults with established CAD at enrolment
- Participants
- 7,024 adults
- Outcome
- First post-enrolment CAD recurrence
- Follow-up
- Median [IQR] 11.6 [7.2-12.7] years
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
CAD recurrence
Recurrent CAD events
2003
28.5%
HR, current smoking
1.35, 95% CI 1.13-1.61
HR per SD increase in age at first CAD
0.74, 95% CI 0.67-0.82
Observational data: associations, not effects.
Further findings
Prediction of CAD recurrence (C index)
- C index, CAD polygenic risk score (PRS)
- 0.58, 95% CI 0.57-0.59
- C index, HDL-C
- 0.57, 95% CI 0.57-0.58
- C index, age at initial CAD event
- 0.57, 95% CI 0.56-0.57
- C index, traditional risk factors model
- 0.644 (0.632-0.654)
- C index, comprehensive model
- 0.676 (0.667-0.686)
Original publication
Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study. Eur Heart J. Published 23 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →