Valvular & structural heart disease
Heart Failure After Left Atrial Appendage Occlusion: Insights from the LAAOS III Randomized Trial
Primary result · Composite HF outcomeResult — go to the resultHazard ratio 1.12 95% CI 0.92–1.37Authors' conclusion
Left atrial appendage occlusion or removal at the time of cardiac surgery does not appear to alter the risk of HF-related hospitalization or death.
Study context
- Population
- Patients with atrial fibrillation (AF) and CHA2DS2-VASc score ≥2 having cardiac surgery for another indication
- Participants
- 4,811 patients
- Comparison
- Surgical LAAO vs no LAAO during cardiac surgery
- LAAOn = 2,379
- Without LAAOn = 2,391reference
- Primary endpoint
- Composite of:
- HF-related hospitalizations
- HF death
- Follow-up
- Mean 3.8 years
Methodological detailslandmark analysis
- Landmark analysis
Primary result
Composite HF outcome
Hazard ratio
1.12
95% CI 0.92–1.37
P = 0.25
Events by treatment group
LAAOvs Without LAAO
HR 1.12 (95% CI 0.92–1.37); P = 0.25
As reported in the abstract
Further findings
Composite HF outcome, first 30 days (landmark)
P = 0.12
Composite HF outcome, after 30 days (landmark)
P = 0.57
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| HF outcomes by closure method (subgroup)Cut-and-sew | 0.93 (0.70–1.23) | P = 0.62 | |
| HF outcomes by closure method (subgroup)Other closure methods | 1.05 (0.77–1.41) | P = 0.77 | |
| 0.512Hazard ratio (log scale) |
Heart failure (HF) outcomes by subgroup (age, sex, BMI, AF type, prior HF, cardiac rhythm, LVEF)
- Consistent results across subgroups
Original publication
Heart Failure After Left Atrial Appendage Occlusion: Insights from the LAAOS III Randomized Trial. Eur J Heart Fail. Published 25 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →