Pulmonary vascular disease & thromboembolism
Heart Rate Control with Landiolol Hydrochloride in Infants with Ventricular Dysfunction and Pulmonary Hypertension
Authors' conclusion
The use of landiolol hydrochloride for HR control of non-arrhythmic tachycardia in critically ill infants is well tolerated. Reduction of HR can be guided quickly and landiolol treatment is associated with an improvement of ventricular dysfunction and PH.
Study context
- Population
- Term and preterm infants with ventricular dysfunction and/or pulmonary hypertension with preexisting tachycardia treated with landiolol, University Children's Hospital Bonn, 2018–2020
- Participants
- 62 participants
- Exposure
- Landiolol in infants born <35 vs >35 weeks gestational age (GA)
- Group An = 29
- Group Bn = 33
- Outcome
- Percentage of patients achieving HR normalization
- Follow-up
- First 24 h of landiolol treatment
Methodological detailssingle-centre, medical chart review
- Single-centre
- Medical chart review
Main finding
As reported in the abstract
Primary endpoint achieved (overall)
57 patients
91.9%
Observational data: associations, not effects.
Further findings
Time to target HR
- Median time to target HR (overall)
- 1.8 (0.3-24) h
Landiolol dosing
μk/kg/min
- Median starting dose
- 8.8 (3.9-25.3)
- Median dosing during first 24 h
- 9.9 (2.8-35.4)
- Median dose at target HR
- 10 (2.4-44.4)
RV dysfunction · 24 h after onset of landiolol
- Improved significantly in Group A
- P = 0.001
- Improved significantly in Group B
- P = 0.045
LV and biventricular dysfunction (Group B) · 24 h after onset of landiolol
- LV dysfunction improved significantly in Group B
- P = 0.004
- Biventricular dysfunction improved significantly in Group B
- P = 0.006
Pulmonary hypertension (PH) severity (Group A) · 24 h
- PH severity improved significantly in Group A
- P < 0.001
Safety
Severe drug-related adverse events · during landiolol treatment
- No severe drug-related adverse event
Original publication
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