Congenital heart disease

Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta

Circ Heart FailPublished prospective cohort study

Authors' conclusion

BP assessment during exercise can improve risk stratification and identify patients who may benefit from intensification of medical therapy.

Study context

Population
Adults with repaired coarctation of the aorta (COA) and healthy controlspatients with COA 41 · healthy controls 41
Participants
41 vs 41
Exposure
COA vs healthy controls
  • COAn = 41
  • Healthy controlsn = 41
Outcome
Prevalence of EIH (systolic BP at peak exercise >210 mm Hg in men or >190 mm Hg in women)
Follow-up
Peak exercise

Main finding

As reported in the abstract

P = 0.004

Observational data: associations, not effects.

Further findings

OutcomeValues
COA with EIH vs COA without EIHCOA without EIH 63%

COA with exercise-induced hypertension (EIH) vs COA without EIH

Those with EIH had higher arterial load at rest and during exercise, worse cardiac dysfunction, pulmonary congestion, and biomarkers of cardiovascular remodeling, despite no significant differences in resting systolic blood pressure (BP)

Original publication

Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta. Circ Heart Fail. Published 5 March 2025. doi:10.1161/circheartfailure.124.012459

Summarised from the published abstract; every number is checked against it

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