Heart failure & cardiomyopathies
Heritability and Causality of QRS Duration and Chronic Heart Failure Risk
Authors' conclusion
This study establishes a causal relationship between shorter QRS duration and increased CHF risk, highlighting the importance of genetic factors in cardiac electrical conduction. Identifying QRS duration as a genetic marker for CHF risk can enhance early diagnosis and personalized treatment strategies.
Study context
- Population
- European individuals in exome-wide association studies (EWAS) dataset for QRS durationQRS duration genome-wide association studies (GWAS) (IEU Open GWAS project) 10,815 · QRS duration EWAS (CHARGE Exome-Chip EKG consortium) 77,898 · chronic heart failure (CHF) GWAS (EMBL-EBI GWAS catalogue) 486,160
- Comparison
- Genetically predicted QRS duration and CHF risk
- Outcome
- Heritability of QRS duration
Methodological detailslinkage disequilibrium score regression (LDSC), sensitivity analyses
- Linkage disequilibrium score regression (LDSC)
- Sensitivity analyses
Main finding
As reported in the abstract
QRS duration heritability, GWAS
16.3%
QRS duration heritability, EWAS
18.5%
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| CHF risk per QRS duration (MR, IVW (MRE)); shorter QRS duration causally associated with increased CHF riskQRS GWAS · IVW (MRE) | 0.84 (0.78–0.91) | P = 2.26E-05 | |
| CHF risk per QRS duration (MR, IVW (MRE)); shorter QRS duration causally associated with increased CHF riskQRS EWAS · IVW (MRE) | 0.98 (0.96–0.99) | P = 6.57E-05 | |
| 0.512Odds ratio (log scale) |
Heritability of CHF
- CHF heritability
- 0.8%
Instrumental variables
- Variants from the GWAS
- Six
- Variants from the EWAS
- 27
- Including those in ion channel-related genes, like CASQ2, SCN5A and SCN10A
Sensitivity analyses (MR-Egger intercept)
- Corrected GWAS: Egger_intercept
- 0.002, P = 0.94
- Corrected EWAS: Egger_intercept
- 0.007, P = 0.38
- Sensitivity analyses confirmed the robustness of these findings
Original publication
Heritability and Causality of QRS Duration and Chronic Heart Failure Risk. ESC Heart Fail. Published 11 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →