Heterogeneity of Lipoprotein(a) Levels Among Hispanic or Latino Individuals Residing in the US
Authors' conclusion
Results of this cohort study suggest that differences in Lp(a) level distribution across the diverse US Hispanic or Latino population may carry important implications for the use of Lp(a) level in ASCVD risk assessment for this group.
Study context
- Population
- Hispanic or Latino adults aged 18 to 74 years living in the US, recruited 2008–2011Lp(a) measured
- Participants
- 16,117 participants
- Exposure
- Lp(a) levels across Hispanic or Latino background groups and genetic ancestry
- Central Americann = 1,704
- Cubann = 2,313
- Dominicann = 1,436
- Mexicann = 6,395
- Puerto Ricann = 2,652
- South Americann = 1,051
- Outcome
- Distribution of Lp(a) levels (quintiles) across demographic groups, incl. Hispanic or Latino background; genetic ancestry across Lp(a) quintiles
Methodological detailsHCHS/SOL, probability sampling, survey-weighted, 4 US metropolitan areas
- HCHS/SOL
- Probability sampling
- Survey-weighted
- 4 US metropolitan areas
Main finding
As reported in the abstract
Lp(a) level
- Overall median (IQR) Lp(a), nmol/L
- 19.7 (7.4-59.7)
Observational data: associations, not effects.
Further findings
Median genetic ancestry, first vs fifth Lp(a) quintile
- West African ancestry, Q1 vs Q5
- 5.5% [3.4%-12.9%] vs 12.1% [5.0%-32.5%]; P < .001
- Amerindian ancestry, Q1 vs Q5
- 32.8% [9.9%-53.2%] vs 10.7% [4.9%-30.7%]; P < .001
- Median (IQR)
Original publication
Heterogeneity of Lipoprotein(a) Levels Among Hispanic or Latino Individuals Residing in the US. JAMA Cardiol. Published 1 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it