Arrhythmias & electrophysiology
High Rate Triggers Increased Atrial Release of BMP10, A Biomarker for Atrial Fibrillation and Stroke, and BMP10 Affects Ventricular Cardiomyocytes
Authors' conclusion
High atrial rates elevate BMP10 expression and release, and higher plasma concentrations of BMP10 are observed in patients with active AF. BMP10 exposure induces transcriptomic changes linked to AF and heart failure in ventricular EHT.
Study context
- Population
- Human iPSC-derived atrial and ventricular engineered heart tissue (EHT); patients with different atrial rhythms at blood draw
- Participants
- 1,370 patients
- Comparison
- High-rate optogenetic pacing vs intrinsic beating rate in atrial EHT; BMP10 exposure in ventricular EHT; plasma BMP10 by atrial rhythm
- Outcome
- BMP10 release from atrial EHT with high-rate optogenetic pacing
Methodological detailshuman iPSC-derived atrial and ventricular engineered heart tissue, optogenetic pacing, Atrial EHTs paced at 3-5 Hz or kept at intrinsic rate for 24 hours up to 15 days; ventricular EHTs exposed to BMP10 for 10 days
- Human iPSC-derived atrial and ventricular engineered heart tissue
- Optogenetic pacing
- Atrial EHTs paced at 3-5 Hz or kept at intrinsic rate for 24 hours up to 15 days; ventricular EHTs exposed to BMP10 for 10 days
Main finding
As reported in the abstract
High-rate optogenetic pacing increased atrial EHT BMP10 release, after a latency of ≥24 h post pacing initiation
≈3-fold
Original publication
High Rate Triggers Increased Atrial Release of BMP10, A Biomarker for Atrial Fibrillation and Stroke, and BMP10 Affects Ventricular Cardiomyocytes. Circ Arrhythm Electrophysiol. Published 15 October 2025. doi:10.
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