Arrhythmias & electrophysiology
Hypothetical interventions and risk of atrial fibrillation by sex and education: application of the parametric g-formula in the Tromsø Study
Authors' conclusion
The population burden of AF could be reduced by modifying lifestyle risk factors.
Study context
- Population
- Women and men from the population-based Tromsø Study, Norway, 1994–2016
- Participants
- 14,923 women
- Exposure
- Hypothetical interventions on six modifiable risk factors vs no intervention
- Outcome
- Long-term risk of AF under hypothetical interventions on smoking, physical activity, alcohol intake, BMI, SBP and DBP
- Follow-up
- Maximum of 22 years
Methodological detailsparametric g-formula, hypothetical interventions
- Parametric g-formula
- Hypothetical interventions
Main finding
As reported in the abstract
Cumulative AF risk · maximum 22 years
Risk reduction
41%
95% CI 17%–61%
Women
Risk reduction
14%
95% CI −7% to 30%
Men
Observational data: associations, not effects.
Further findings
Atrial fibrillation (AF) risk with BMI lowered to ≤ 25 kg/m² (most effective single intervention)
| Lower risk (CI) | |
|---|---|
| Women | 16% (4%–25%) |
| Men | 14% (6%–23%) |
| Outcome | Estimate |
|---|---|
| AF risk with sufficient physical activityWomen | lower risk 7% (CI −4% to 18%) |
| AF risk with sufficient physical activityMen | increased risk 8% (CI −2% to −13%) |
AF risk with sufficient physical activity
- Significant sex-differences in relative risk reduction
Risk reduction by education level
- No association between education level and differences in risk reduction by any intervention
Original publication
Hypothetical interventions and risk of atrial fibrillation by sex and education: application of the parametric g-formula in the Tromsø Study. Eur J Prev Cardiol. Published 19 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →