Valvular & structural heart disease

Ideal Navitor Implant Depth for Redo-TAVR Feasibility and Coronary Access: A Computed Tomography (CT) Simulation Study

JACC AdvPublished CT simulation study

Authors' conclusion

In our CT simulation study, redo-TAVR and coronary access were predicted to be the most favorable with initial Navitor implant depth of 3 mm and redo-S3 implanted lower at Node 2. In vivo analysis will help confirm these findings.

Study context

Population
Patients with native aortic stenosis with pre-TAVR CTs
Participants
2,050 pre-TAVR CTs
Comparison
Redo-TAVR and coronary access with S3 after initial Navitor valve, based on various implant depths
Outcome
Redo-TAVR unfeasible

Main finding

As reported in the abstract

P < 0.0001

Further findings

Coronary access

Least challenging with initial Navitor depth at 3 mm and redo-S3 implanted lower at Node 2
P < 0.0001

Results by Navitor valve size

Results similar across all Navitor valve sizes

Commissural alignment in Navitor

Improved redo-TAVR feasibility only when implanted at 5 mm

Original publication

Ideal Navitor Implant Depth for Redo-TAVR Feasibility and Coronary Access: A CT Simulation Study. JACC Adv. Published 8 August 2025. doi:10.1016/j.jacadv.2025.102055

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