Arrhythmias & electrophysiology
Identification, multimodal characterization, and clinical outcomes of pre-atrial fibrillation subclasses
Authors' conclusion
Subclassification of Pre-AF using ECG, echocardiography, and N-terminal pro-B-type natriuretic peptide has prognostic implications but is not specifically associated with diagnosis of incident AF in routine care.
Study context
- Population
- Individuals with high risk of developing AF (according to the FIND-AF risk score), who underwent echocardiographic, electrocardiogram (ECG), and biomarker assessmentmean age 74.9 [±5.8] years, 50% women
- Participants
- 254 individuals
- Exposure
- Pre-atrial fibrillation (Pre-AF) subclasses
- Pre-AF 1n = 82
- Pre-AF 2n = 90
- Pre-AF 3n = 82
- Outcome
- Composite of:
- Major adverse cardiovascular
- Cerebrovascular
- Cognitive events (incident AF, heart failure, ischemic stroke/transient ischemic attack, myocardial infarction, dementia, or cardiovascular death)
- Follow-up
- Median 24.4 months (interquartile range 19.6-26.3 months)
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
N-terminal pro-B-type natriuretic peptide
Left atrial volume
- N-terminal pro-B-type natriuretic peptide: P < .001
- Left atrial volume: P < .001
Original publication
Identification, multimodal characterization, and clinical outcomes of pre-atrial fibrillation subclasses. Heart Rhythm. Published 26 June 2026. doi:10.
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