Arrhythmias & electrophysiology

Identifying the optimal site for intentional right atrial appendage perforation for pericardial CO2 insufflation: A cardiac CT anatomic evaluation

Heart RhythmPublished cardiac CT anatomic evaluation

Authors' conclusion

The high septal anterior RAA offers the most favorable anatomic clearance for transatrial pericardial access, whereas the lateral and remaining septal walls lie in close proximity to the parietal pericardium and aorta.

Study context

Population
Patients undergoing contrast-enhanced cardiac computed tomographyconsecutive patients (24 men, 57 ± 12 years), additional validation cohort of 8 patients undergoing trans-RAA carbon dioxide insufflation and 2 patients with aortic dilation
Participants
50 patients
Comparison
Distances from RAA segments to adjacent epicardial structures
Outcome
Distance from lateral RAA segments to parietal pericardium
Methodological detailscontrast-enhanced cardiac computed tomography, consecutive patients
  • Contrast-enhanced cardiac computed tomography
  • Consecutive patients

Main finding

As reported in the abstract

Lateral RAA segments directly contacted the parietal pericardium

0 mm

interquartile range 0–0 mm

Further findings

Distance from posterior and midseptal segments to aorta

Posterior and midseptal segments closely approximated the aorta
3.8 mm [2.3-8.2 mm]

Visible pericardial space

Only the septal anterior region bordered a visible pericardial space between the parietal pericardium, aorta, right coronary artery (RCA), and right ventricular outflow tract

Separations at the high septal anterior plane

mm

Right ventricular outflow tract
12.4
Aorta
6.3
Parietal pericardium
9.8
RCA
13.4
  • Greatest separations

RCA branches within 5 mm of the RAA

Patients with RCA branches coursing within 5 mm of the RAA
4

Validation cohort

Results were consistent in an additional validation cohort of 8 patients undergoing trans-RAA carbon dioxide insufflation and 2 patients with aortic dilation

Original publication

Identifying the optimal site for intentional right atrial appendage perforation for pericardial CO2 insufflation: A cardiac CT anatomic evaluation. Heart Rhythm. Published 25 February 2026. doi:10.1016/j.hrthm.2026.02.026

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