Heart failure & cardiomyopathies
Imaging modality for left ventricular ejection fraction estimation and effect of implantable cardioverter-defibrillator on mortality in patients with heart failure
Authors' conclusion
We found no evidence that in patients with HF and LVEF ≤35%, the effect of ICD on mortality varied by the noninvasive imaging method used to measure LVEF.
Study context
- Population
- Patients with heart failure (HF) and left ventricular ejection fraction (LVEF) ≤35% in SCD-HeFT with LVEF measured by 2DE or MUGA2DE n = 971
- Participants
- 1,386 patients
- Comparison
- ICD vs placebo, by LVEF imaging modality
- ICDn = 692
- Placebon = 694reference
- Primary endpoint
- All-cause mortality, by imaging subgroup (2DE vs MUGA)
Methodological detailssubgroup analysis
- Subgroup analysis
Primary result
As reported in the abstract
All-cause mortality by imaging subgroup
ICD vs PlaceboHazard ratio (97.5% CI)
2DE subgroup
0.79(0.60–1.04)
MUGA subgroup
0.72(0.46–1.11)
Further findings
| Outcome | ICD | Placebo | HR (97.5% CI) | |
|---|---|---|---|---|
| All-cause mortality, overall | 23.1% | 29.7% | 0.77 (0.61–0.97) | |
| 0.512Hazard ratio (log scale) |
Cardiac and arrhythmic mortality
- Similar associations observed
Original publication
Imaging modality for left ventricular ejection fraction estimation and effect of implantable cardioverter-defibrillator on mortality in patients with heart failure. Heart Rhythm. Published 11 March 2023. doi:10.
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