Impact of caffeine on adenosine-induced myocardial blood flow and the efficacy of increasing adenosine dose to overcome the antagonistic effect of caffeine in healthy adults
Authors' conclusion
Although the antagonistic effects of caffeine may slightly be overcome by increasing the adenosine dose, an HR increase > 10 bpm may be an unreliable criterion for increasing doses of adenosine. Therefore, caffeine restriction is essential for myocardial perfusion imaging with adenosine.
Study context
- Population
- Healthy volunteers undergoing adenosine stress CMR10 males and 10 females, age 30 ± 3 years
- Participants
- 20 volunteers
- Comparison
- Caffeine ingestion and restriction
Primary result
As reported in the abstract
MBF · adenosine dose of 120 µg/kg/min
P < 0.001
Further findings
MBF at target HR · significantly lower with caffeine
P = 0.012
| Outcome | Caffeine | Placebo | P value |
|---|---|---|---|
| Increased dose of adenosine required to achieve the target HR | Seven events | three events | P = 0.012 |
| Correlation of myocardial T1 with MBF | 0.74 | 0.52 | |
| P | P < 0.001 | P = 0.018 |
- Correlation of myocardial T1 with myocardial blood flow (MBF): only myocardial T1 correlated significantly with MBF
Original publication
Impact of caffeine on adenosine-induced myocardial blood flow and the efficacy of increasing adenosine dose to overcome the antagonistic effect of caffeine in healthy adults. Eur Heart J Cardiovasc Imaging. Published 11 August 2025. doi:10.
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