Sex- and age-specific normal values for automated quantitative pixel-wise myocardial perfusion cardiovascular magnetic resonance
Authors' conclusion
Fully automated in-line CMR myocardial perfusion mapping produces similar normal values to the published CMR and PET literature. There is a significant increase in rest and stress MBF, but not MPR, in females and a reduction of stress MBF and MPR with advancing age
Study context
- Population
- Healthy volunteers undergoing adenosine stress and rest myocardial perfusion cardiovascular magnetic resonance (CMR)
- Participants
- 151 healthy volunteers
- Exposure
- Females vs Males
- Outcome
- Sex- and age-specific normal values for stress and rest CMR myocardial blood flow (MBF)
Methodological detailstwo centres
- Two centres
Main finding
As reported in the abstract
Mean rest myocardial blood flow (MBF), all subjects
0.62 ± 0.13 mL/g/min
Mean stress MBF, all subjects
2.24 ± 0.53 mL/g/min
Mean myocardial perfusion reserve (MPR), all subjects
3.74 ± 1.00
Observational data: associations, not effects.
Further findings
Rest MBF by sex
P < 0.01
Stress MBF by sex
P = 0.001
Correlation with increasing age
- Stress MBF vs age, r
- −0.43, P < 0.001
- MPR vs age, r
- −0.34, P < 0.001
Original publication
Sex- and age-specific normal values for automated quantitative pixel-wise myocardial perfusion cardiovascular magnetic resonance. Eur Heart J Cardiovasc Imaging. Published 2 December 2022. doi:10.
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