Impact of Age-Related Change in Caval Flow Ratio on Hepatic Flow Distribution in the Fontan Circulation
Authors' conclusion
Our analysis provided quantitative insights into the impact of the changing caval inflows on Fontan's long-term HFD, highlighting the importance of SVC:IVC variations over time on Fontan's long-term hemodynamics.
Study context
- Population
- Patients with single ventricle heart disease after Fontan operation60 CFD patient models
- Participants
- 414 patients
- Comparison
- Extracardiac vs Lateral tunnel
- Extracardiacn = 30
- Lateral tunneln = 30
- Outcome
- Hepatic flow distribution (HFD) in response to age-related changes in SVC:IVC flow ratio
- Follow-up
- Ages 3, 8 and 15 years
Methodological detailsCMR data, patient-specific computational fluid dynamics modelling
- CMR data
- Patient-specific computational fluid dynamics modelling
Main finding
As reported in the abstract
Correlation of inferior vena cava (IVC) flow distribution with hepatic flow distribution (HFD), superior vena cava (SVC):IVC 2 (age 3)
0.87
Correlation of IVC flow distribution with HFD, SVC:IVC 0.5 (age 15+)
0.64
Original publication
Impact of Age-Related Change in Caval Flow Ratio on Hepatic Flow Distribution in the Fontan Circulation. Circ Cardiovasc Imaging. Published 3 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it