Arrhythmias & electrophysiology
Impact of early bleeding on long-term mortality after left atrial appendage occlusion
Main finding · Early bleeding incidence; all-cause mortalityResult — go to the resultAdjusted hazard ratio 2.07 95% CI 1.15–3.75Authors' conclusion
One in 7 patients experience a nonprocedural bleeding event within 90 days of LAAO. Early bleeding after LAAO is associated with a higher all-cause mortality risk during mid-term follow-up.
Study context
- Population
- Patients undergoing Left Atrial Appendage Occlusion (LAAO) at Mayo Clinic, 2018–2023
- Participants
- 592 patients
- Exposure
- Early bleeding vs no early bleeding after LAAO
- Early bleedingn = 83
- Outcome
- Incidence of early bleeding post-LAAO and its association with long-term (all-cause) mortality
- Follow-up
- Median 14.4 months (IQR 4.2-27.9)
Methodological detailssingle-centre
- Single-centre
Main finding
Early bleeding incidence; all-cause mortality · median follow-up 14.4 months
Adjusted hazard ratio
2.07
95% CI 1.15–3.75
P = 0.02
Events by group
Early bleeding
14.0%
83
Early bleedingvs No early bleeding
adjusted HR 2.07 (95% CI 1.15–3.75); P = 0.02
As reported in the abstract
- Majority of early bleeding minimal or minor
- minimal (63.4%) or minor (17.3%)
Observational data: associations, not effects.
Further findings
- Independent predictors: history of intracranial bleeding, nonparoxysmal AF, CHA2DS2-VASc score, early device-related thrombosis
- Antithrombotic therapy at discharge not associated with early nonprocedural bleeding
Original publication
Impact of early bleeding on long-term mortality after left atrial appendage occlusion. Heart Rhythm. Published 18 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →