Valvular & structural heart disease
Impact of Female Sex on Survival and Outcomes After Mitral Valve Surgery: A Meta-Analysis
Pooled result · Primary mitral valve replacementResult — go to the resultOdds ratio 2.15 95% CI 1.62–2.84Authors' conclusion
Women are more likely to undergo mitral valve replacement and have higher recurrent regurgitation, whereas adjusted mortality is similar, suggesting potential benefit of repair-focused strategies when feasible.
Study context
- Population
- Men and women undergoing surgical mitral valve surgerypatients in sixteen studies
- Participants
- 42,587 men
- Comparison
- Female sex vs men undergoing surgical mitral valve surgery
- Outcome
- Primary mitral valve replacement
Methodological detailsrandom-effects models, time-to-event data reconstructed, meta-regression
- Random-effects models
- Time-to-event data reconstructed
- Meta-regression
Pooled result
As reported in the abstract
Odds ratio
2.15
95% CI 1.62–2.84
By group
Womenvs Men
OR 2.15 (95% CI 1.62–2.84)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| In-hospital mortality | OR 1.38 (95% CI 1.27–1.50) | |
| All-cause mortalityWomenvs MenUnadjusted | HR 1.35 (95% CI 1.25–1.47) | |
| All-cause mortalityWomenvs MenAdjusted; not significantly different | HR 0.96 (95% CI 0.91–1.01) | |
| Recurrent MRWomenvs MenUnadjusted | HR 1.57 (95% CI 1.14–2.15) | |
| Recurrent MRWomenvs MenAdjusted; remained higher in women | HR 1.68 (95% CI 1.13–2.51) | |
| ReoperationWomenvs MenUnadjusted; similar | HR 1.35 (95% CI 0.96–1.89) | |
| ReoperationWomenvs MenAdjusted; not significantly different | HR 1.33 (95% CI 0.81–2.18) | |
| 0.20.5125Ratio (log scale) |
| Outcome | Mean difference (years) (95% CI) | |
|---|---|---|
| AgeWomen significantly older than men | 2.8 (1.5–4.0) | |
| −20246Difference, years (linear scale) |
Proportion of women in cohort
- Women accounted for (95% CI: 36%-42%)
- 39%
Meta-regression: mitral valve replacement proportion and mortality in women
- Higher mitral valve replacement proportion was associated with increased mortality in women
Original publication
Impact of Female Sex on Survival and Outcomes After Mitral Valve Surgery: A Meta-Analysis. JACC Adv. Published 20 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →