Impact of Heart Failure on All-Cause Mortality in COVID-19: Findings from the Eurasian International Registry

doi:10.1002/ehf2.14243

Heart failure & cardiomyopathies

Impact of Heart Failure on All-Cause Mortality in COVID-19: Findings from the Eurasian International Registry

ESC Heart FailPublished 14 Dec 2022International registry study

Main finding · In-hospital all-cause mortalityResultOdds ratio 4.614 95% CI 3.633–5.859

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Authors' conclusion

Hospitalized COVID-19 patients with CHF have an increased risk of in-hospital all-cause mortality, which remains high 6 months after discharge.

Study context

Population: Patients hospitalized with COVID-19, ACTIV registry (Armenia, Belarus, Kazakhstan, Kyrgyzstan, Moldova, Russian Federation, Uzbekistan)917 (16.3%) with CHF
Participants: 5,616 patients

Exposure: CHF vs no CHF
CHFn = 917
Outcome: All-cause mortality in hospital and at 3 and 6 months of follow-up
Follow-up: In-hospital, 3 and 6 months

Methodological detailsmulticentre, 26 centres in seven countries

Multicentre
26 centres in seven countries

Main finding

In-hospital all-cause mortality

Odds ratio

4.614

95% CI 3.633–5.859

P < 0.001

By group

CHF17.7%

Without CHF4.0%

CHFvs Without CHF

OR 4.614 (95% CI 3.633–5.859); P < 0.001

As reported in the abstract

Total in-hospital mortality: 7.6%

Observational data: associations, not effects.

Further findings

Outcome	← Lower odds ←→ Higher odds →	OR (95% CI)	P value
In-hospital all-cause mortality by NYHA classNYHA III–IVvs Without CHF	0.10.31310	6.124 (4.538–8.266)	P < 0.001
In-hospital all-cause mortality by NYHA classNYHA I–IIvs Without CHF	0.10.31310	2.446 (1.831–3.267)	P < 0.001
Mortality, ischaemicvs non-ischaemic CHF58% higher risk	0.10.31310	1.58 (1.05–2.45)	P = 0.030
	0.10.31310Odds ratio (log scale)

All-cause mortality · first 3 months of follow-up

P < 0.001

CHF10.32%

Without CHF1.83%

All-cause mortality, NYHA II–IV as risk factor · 6 months of follow-up

	← Lower odds ←→ Higher odds →	OR (95% CI)	P value
NYHA II–IV	0.050.21520	5.343 (2.717–10.508)	P < 0.001
	0.050.21520Odds ratio (log scale)

Original publication

Impact of Heart Failure on All-Cause Mortality in COVID-19: Findings from the Eurasian International Registry. ESC Heart Fail. Published 14 December 2022. doi:10.1002/ehf2.14243

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