Arrhythmias & electrophysiology
Impact of Posterior Left Atrial Voltage on Ablation Outcomes in Persistent Atrial Fibrillation: CAPLA Substudy
Corrected 23 Oct 2026: Measure wording clarified; no values changed.
Authors' conclusion
In patients with PsAF undergoing catheter ablation, posterior LVA was associated with a significant increase in atrial arrhythmia recurrence. However, the addition of PWI in those with posterior LVA did not reduce atrial arrhythmia recurrence over PVI alone.
Study context
- Population
- Persistent AF patients undergoing catheter ablation with posterior wall low voltage areas (bipolar voltage <0.5 mV)posterior LVA in 69 (32.9%)
- Participants
- 210 patients
- Comparison
- Pulmonary vein isolation (PVI) with posterior wall isolation (PWI) vs PVI alone in persistent AF with posterior wall LVA
- Primary endpoint
- Freedom from any documented atrial arrhythmia >30 s off antiarrhythmic medication after a single ablation, in patients with posterior LVA
- Follow-up
- 12 months
Methodological detailsmulticentre, 1:1 randomisation, offline review of pre-ablation voltage mapping
- Multicentre
- 1:1 randomisation
- Offline review of pre-ablation voltage mapping
Primary result
As reported in the abstract
Freedom from atrial arrhythmia recurrence (posterior LVA)
Hazard ratio
0.95
95% CI 0.51–1.79, event not clearly stated
P = 0.95
By group
Further findings
LVA in other atrial regions, posterior LVA vs no posterior LVA
P < 0.01
Left atrial diameter, posterior LVA vs no posterior LVA
P < 0.01
| Outcome | LVA | No LVA | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Atrial arrhythmia recurrence, posterior LVAvs no posterior LVA · 12 months | 56.5% | 41.4% | 1.51 (1.01–2.27) | P = 0.04 | |
| 0.512Hazard ratio (log scale) |
Original publication
Impact of Posterior Left Atrial Voltage on Ablation Outcomes in Persistent Atrial Fibrillation: CAPLA Substudy. JACC Clin Electrophysiol. Published 13 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →