Arrhythmias & electrophysiology
Left Atrial Low Voltage Areas and Heart Failure in Patients with Atrial Fibrillation: Implication of the Atrial Myopathy
Main finding · Composite of HF hospitalization or deathResult — go to the resultAdjusted hazard ratio 1.55 95% CI 1.16–2.10Authors' conclusion
LVA presence and its extent were associated with frequent HF hospitalization and death.
Study context
- Population
- Consecutive patients undergoing initial ablation for atrial fibrillation (AF); LA low-voltage areas (LVAs) = bipolar peak-to-peak voltage <0.50 mV
- Participants
- 1,481 patients
- Exposure
- Small or extensive LA low-voltage areas vs no LVA
- No LVAn = 1,129reference
- Small LVAn = 217
- Extensive LVAn = 135
- Outcome
- Composite of:
- Heart failure (HF) hospitalization
- Death
- Follow-up
- 3-year follow up
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
3-year follow-up
Adjusted hazard ratio
1.55
95% CI 1.16–2.10
P = 0.003
Each additional step of LVA classification
adjusted HR 1.55 (95% CI 1.16–2.10); P = 0.003
Each additional step of LVA classification, as printed
- Composite endpoint occurred more frequently with larger LVAs (no vs small vs extensive LVA)
- 3.3% vs. 6.5% vs. 13.3%, P < 0.0001
Observational data: associations, not effects.
Original publication
Left Atrial Low Voltage Areas and Heart Failure in Patients with Atrial Fibrillation: Implication of the Atrial Myopathy. ESC Heart Fail. Published 10 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it