Heart failure & cardiomyopathies
Incidence of Heart Failure Related to Co-Occurrence of Gestational Hypertensive Disorders and Gestational Diabetes
Authors' conclusion
The co-occurrence of GDM and GHTD was associated with a significantly high risk of incident HF.
Study context
- Population
- Women with a livebirth singleton delivery in Ontario (Canada), July 2007–March 2018, without prepregnancy DM, hypertension, heart failure (HF) or CAD489 HF events over 8 years
- Participants
- 885,873 women
- Exposure
- Gestational diabetes mellitus (GDM) and/or gestational hypertensive disorders (GHTD) vs no GDM and no GHTD
- Isolated GDMn = 54,015
- Isolated GHTDn = 43,750
- GDM and GHTDn = 4,960
- Outcome
- Incident HF
- Follow-up
- From index pregnancy until March 31, 2020
Methodological detailshealth care administrative databases
- Health care administrative databases
Main finding
As reported in the abstract
Each group vs No-GDM and no-GHTDAdjusted hazard ratio (95% CI)
Isolated GDM
1.44(1.02–2.04)
Isolated GHTD
1.65(1.17–2.31)
GDM and GHTD
2.64(1.24–5.61)
Observational data: associations, not effects.
Further findings
| Outcome | aRR (95% CI) | |
|---|---|---|
| Peripartum cardiomyopathyGDM and GHTDvs No-GDM and no-GHTD | 7.30 (6.92–7.58) | |
| Peripartum cardiomyopathyIsolated GHTDvs No-GDM and no-GHTD | 7.40 (7.23–7.58) | |
| 0.10.31310Adjusted relative risk (log scale) |
Original publication
Incidence of Heart Failure Related to Co-Occurrence of Gestational Hypertensive Disorders and Gestational Diabetes. JACC Adv. Published 30 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →