Arrhythmias & electrophysiology
Incidence of Pacing-Induced Cardiomyopathy Among Patients With Leadless Versus Transvenous Ventricular Pacemakers
Authors' conclusion
The incidence and characteristics of pacing-induced cardiomyopathy are similar between LP and TVP. However, patients with LP are less likely to undergo cardiac resynchronization therapy upgrade.
Study context
- Population
- Patients who underwent implantation of leadless pacemakers (LP) and transvenous pacemakers (TVP) between January 1, 2016, and January 1, 2023, TriNetX Analytics Network database
- Participants
- 2,594 propensity score-matched patients
- Comparison
- Leadless versus transvenous ventricular pacemakers
- Outcome
- Incidence of pacing-induced cardiomyopathy (new diagnosis of systolic heart failure or left ventricular ejection fraction <50%)
- Follow-up
- From the index hospitalization through December 2024; median 2.4 years
Main finding
As reported in the abstract
P = 0.187
- Incident cases of PCM
- 422
Further findings
Pacing-induced cardiomyopathy in patients with pacing indications of complete heart block or atrioventricular nodal ablation (subgroup)
P = 0.948
Cardiac resynchronization therapy upgrade · LP less likely to undergo upgrade
P = 0.014
| Outcome | LP | TVP |
|---|---|---|
| Baseline characteristics | baseline LVEF 63 ± 7 | baseline LVEF 64 ± 8 |
- Baseline characteristics — median age
- 73.8 years (±15)
Mean drop in left ventricular ejection fraction
- Comparable between both groups
Original publication
Incidence of Pacing-Induced Cardiomyopathy Among Patients With Leadless Versus Transvenous Ventricular Pacemakers. Circ Arrhythm Electrophysiol. Published 25 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →