Increased cancer incidence in patients with pre-existing heart failure: results from a French nationwide cohort study
Authors' conclusion
Patients with a history of HF have a higher risk of developing cancer than the general population.
Study context
- Population
- Adults with a first heart failure (HF) diagnosis 2010–2019 and no history of cancer, French National Administrative Health Data Systemmatched cohort
- Participants
- 330,867 vs 992,601
- Exposure
- Pre-existing HF vs no known HF
- HFn = 330,867
- Controlsn = 992,601reference
- Outcome
- Incidence of cancer
Methodological detailsnationwide, matched (sex and age, 3:1)
- Nationwide
- Matched (sex and age, 3:1)
Main finding
As reported in the abstract
First cancer
HF vs ControlsEstimate (CI)P value
First cancer
unadjusted sHR 1.12(1.11–1.13)
P < 0.001Adjusted for major comorbidities, age, sex, year of diagnosis, region, tobacco and alcohol
adjusted sHR 1.06(1.04–1.07)
P < 0.0001Observational data: associations, not effects.
Further findings
Attributable risk of new cancer after HF
- Interval as printed
Cancer type
- Increased risk for most solid malignancies (especially colorectal and lung cancer) and for multiple myeloma
Original publication
Increased cancer incidence in patients with pre-existing heart failure: results from a French nationwide cohort study. Eur J Prev Cardiol. Published 20 March 2025. doi:10.
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