Increased Platelet FcɣRIIa Identifies Patients at Greater Risk of Multiple Cardiovascular Events After Myocardial Infarction
Authors' conclusion
High pFCG is associated with a greater risk of both first and additional ischemic endpoints. The strong association of pFCG with a greater risk of recurrent ischemic events may be useful to inform clinical decision-making.
Study context
- Population
- Patients with type 1 myocardial infarction (MI) with at least 2 of: age ≥65 years, multivessel coronary artery disease, prior MI, chronic kidney disease, and diabetespatients with type 1 MI enrolled
- Participants
- 765 patients
- Exposure
- pFCG in patients with and without subsequent ischemic and bleeding events
- No eventsn = 562
- Bleeding events alonen = 45
- Single ischemic eventn = 101
- Bleeding + ischemic eventsn = 29
- Multiple ischemic eventsn = 23
- Fatal MIn = 5
- Outcome
- Average pFCG (molecules/platelet) by patient group
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Average pFCG expression in patients with bleeding (without ischemia) | bleeding events alone average 1,491 ± 517 molecules/platelet |
Ischemic events associated with high pFCG (accentuated by additional ischemic endpoints) · between 6 months and 1 year
- HR
- 2.7
- 95% CI
- 1.82-4.02
- P
- P < 0.0001
- Early ischemic events associated with high pFCG were driven by first ischemic endpoints
Average pFCG expression in patients with bleeding (without ischemia)
- Similar to that in patients without ischemia or bleeding
Endpoint counts
- Ischemic endpoints (MI, stroke, and death)
- 158
- Bleeding endpoints (Bleeding Academic Research Consortium 2, 3, and 5)
- 74
Original publication
Increased Platelet FcɣRIIa Identifies Patients at Greater Risk of Multiple Cardiovascular Events After Myocardial Infarction. JACC Adv. Published 13 July 2026. doi:10.
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