Predictive Value of Platelet FcγRIIa in Patients Treated With Percutaneous Coronary Intervention (PCI) Compared With Medical Therapy Alone After Myocardial Infarction
Authors' conclusion
Quantifying pFCG discerned the risk of subsequent cardiovascular events among patients treated with medical therapy alone or PCI. This prognostic information will be useful for clinical decisions that balance ischemic and bleeding risk.
Study context
- Population
- Patients hospitalized for type 1 myocardial infarction (MI) (ST-segment-elevation and non-ST-segment-elevation) with at least 2 of: aged ≥65 years, multivessel coronary artery disease, prior MI, chronic kidney disease, or diabetespatients in the trial, subgroup analysis of patients treated with PCI or medical management alone
- Participants
- 800 patients
- Exposure
- High vs low platelet FcɣRIIa (pFCG), quantified by flow cytometry, in patients treated with PCI or medical management alone
- Medical therapy alonen = 151
- PCIn = 490
- Outcome
- Composite of:
- MI
- Stroke
- Death
Methodological detailssubgroup analysis, 25-center
- Subgroup analysis
- 25-center
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
pFCG test, medical treatment grouppFCG discrimination of risk in the medical treatment group
2.29(1.18–4.41)
P = 0.014pFCG test, PCI grouppFCG discrimination of risk in the PCI group
2.57(1.41–4.69)
P = 0.002Observational data: associations, not effects.
Safety
Clinically relevant bleeding
| Hazard ratio (95% CI) | ||
|---|---|---|
| pFCG, medical treatment group | 1.22 (0.29–5.10) | |
| pFCG, PCI group | 1.56 (0.67–3.61) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Predictive Value of Platelet FcγRIIa in Patients Treated With PCI Compared With Medical Therapy Alone After Myocardial Infarction. Circ Cardiovasc Interv. Published 26 March 2025. doi:10.
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