Platelet FcγRIIa as a Marker of Cardiovascular Risk After Myocardial Infarction
Main finding · MI, stroke, deathResult — go to the resultHazard ratio 2.09 95% CI 1.34–3.26Authors' conclusion
Quantifying pFCG identifies patients at higher and lower risk of subsequent cardiovascular events.
Study context
- Population
- Patients with type 1 myocardial infarction (MI) (STEMI and NSTEMI) with ≥2 of: age ≥65 years, multivessel CAD, previous MI, CKD or DM
- Participants
- 800 patients25 centres
- Exposure
- High vs low platelet FcγRIIa
- Outcome
- Composite of:
- MI
- Stroke
- Death
Methodological detailsmulticentre, noninterventional, 25 centres
- Multicentre
- Noninterventional
- 25 centres
Main finding
MI, stroke, death
Hazard ratio
2.09
95% CI 1.34–3.26
P = 0.001
High pFCGvs Low pFCG
HR 2.09 (95% CI 1.34–3.26); P = 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| DeathHigh pFCGvs Low pFCG | 2.57 (1.50–4.40) | P = 0.001 | |
| MIHigh pFCGvs Low pFCG | 3.24 (1.64–6.37) | P = 0.001 | |
| 0.10.31310Hazard ratio (log scale) |
Antithrombotic therapy (aspirin, P2Y12 inhibitors, anticoagulants)
- Similar in high and low pFCG
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Platelet FcγRIIa as a Marker of Cardiovascular Risk After Myocardial Infarction. J Am Coll Cardiol. Published 29 October 2024. doi:10.
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