Valvular & structural heart disease
Incremental prognostic value of left ventricular and left atrial strains in moderate aortic stenosis
Authors' conclusion
In moderate AS, reduced LV-GLS and LARS have incremental prognostic values and can refine risk stratification to identify high-risk patients.
Study context
- Population
- Patients with moderate aortic stenosis (AS) (median age 74 years, men 55%)
- Participants
- 923 patients
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
Methodological detailsLV global longitudinal strain (LV-GLS) and LA reservoir strain (LARS) measured by speckle-tracking echocardiography
- LV-GLS and LARS measured by speckle-tracking echocardiography
Main finding
As reported in the abstract
All-cause mortality and HF hospitalization · median 5.9 years
- Primary endpoint occurred
- 186 patients (20.2%)
- Median LV-GLS
- 17.7% (IQR 14.8-19.7%)
- Median LARS
- 24.5% (IQR 18.7-29.3%)
- LV-GLS, adjusted HR
- 0.92 (0.87-0.97) (95% CI)
- LARS, adjusted HR
- 0.97 (0.95-0.99) (95% CI)
- Optimal cut-offs
- LV-GLS < 17% and LARS < 22%
- Both reduced LV-GLS and LARS: worst outcomes
- log-rank P < 0.001
Observational data: associations, not effects.
Further findings
Incremental prognostic value of LV-GLS < 17% and LARS < 22%
- Incremental prognostic value on top of other clinical and echocardiographic variables
Original publication
Incremental prognostic value of left ventricular and left atrial strains in moderate aortic stenosis. Eur Heart J Cardiovasc Imaging. Published 5 November 2024. doi:10.
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