Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis
Authors' conclusion
The circulating metabolome of interstage SVHD infants differs significantly from controls and is further disrupted after Stage 2.
Study context
- Population
- Interstage infants with single ventricle heart disease (SVHD) undergoing Stage 2 palliation
- Participants
- 52 vs 48
- Exposure
- Interstage SVHD infants vs healthy infants; pre-Stage 2 vs post-Stage 2
- SVHDn = 52
- Controlsn = 48reference
- Outcome
- Circulating metabolome (175 metabolites, targeted metabolomic phenotyping) and its association with pulmonary vascular inadequacy
Main finding
As reported in the abstract
Circulating metabolome
Metabolites differing between SVHD and controls (of 175)
74
Metabolic pathways altered in SVHD vs controls (of 39), incl. pentose phosphate and arginine metabolism
27
Metabolites differing in SVHD between timepoints
71
Pathways altered postoperatively (of 39), incl. arginine and tryptophan metabolism
33
Observational data: associations, not effects.
Further findings
Association with adverse outcomes
- Trend toward increased preoperative methionine metabolites with higher pulmonary vascular resistance
- Trend toward higher postoperative tryptophan metabolites with greater postoperative hypoxemia
Original publication
Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis. JACC Adv. Published 27 January 2023. doi:10.
Summarised from the published abstract; every number is checked against it