Heart failure & cardiomyopathies
Intracardiac Energy Inefficiency During Decompensated and Compensated Heart Failure
Main finding · Average LV-ELResult — go to the resultDifference +18 mE/m·LAuthors' conclusion
Energy inefficiency in LV was apparent even in stable HF patients and significant under acute decompensated conditions, particularly in HF with preserved EF and clinical scenario 1.
Study context
- Population
- Patients admitted for decompensated heart failure (HF); intracardiac energy loss by echo-vector flow mapping50 HF, 40 non-HF
- Participants
- 50 / 50 / 40
- Exposure
- Decompensated vs compensated HF
- Decompensated HFn = 50
- Compensated HFn = 50
- Non-HFn = 40reference
- Outcome
- Average left ventricle (LV) energy loss (EL)
- Follow-up
- Admission (decompensated) and discharge (compensated)
Main finding
Average LV-EL
Difference
+18 mE/m·L
P = 0.03
By group
Decompensated HF
55
mE/m·L
Compensated HF
40
mW/m·L
Non-HF
26
mW/m·L
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference (mW/m·L) | P value |
|---|---|---|
| Decompensated vs compensated LV-EL, by subgroupDecompensated HF vs Compensated HF · non-HFrEF | +19 | P = 0.009 |
| Decompensated vs compensated LV-EL, by subgroupDecompensated HF vs Compensated HF · clinical scenario 1 | +23 | P = 0.008 |
Independent risk factors for high LV-EL (multivariable)
- Age, SBP, LVEF and absence of COPD, regardless of HF
- eGFR independent risk factor for decrease in LV-EL under decompensated conditions
BP, NT-proBNP, ejection fraction (EF)
- BP and NT-proBNP significantly higher and EF significantly lower in decompensated vs compensated HF
Original publication
Intracardiac Energy Inefficiency During Decompensated and Compensated Heart Failure. ESC Heart Fail. Published 27 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →