Arrhythmias & electrophysiology
Is left bundle branch area pacing the optimal pacing strategy for bradyarrhythmia with preserved ejection fraction? A network meta-analysis
Pooled result · Composite of all-cause mortality and hospitalization for heart failureResult — go to the resultOdds ratio 0.42 95% CI 0.25–0.70Authors' conclusion
LBBAP has the potential to be the first-line CPP strategy in bradyarrhythmia with preserved LVEF, owing to its efficacy in reducing hospitalization for heart failure and all-cause mortality.
Study context
- Population
- Adults who underwent pacing for bradyarrhythmia with preserved left ventricular ejection fraction (LVEF) (mean LVEF of at least 50% or less than 10% of heart failure patients)
- Participants
- 8,795 adults29 studies
- Comparison
- Head-to-head comparisons among biventricular pacing (BiVP), left bundle branch area pacing (LBBAP), His-bundle pacing (HBP), and right ventricular pacing (RVP)
- Outcome
- Composite of:
- All-cause mortality
- Hospitalization for heart failure
Methodological detailshead-to-head comparisons
- Head-to-head comparisons
Pooled result
As reported in the abstract
Odds ratio
0.42
95% CI 0.25–0.70
P = 0.001
LBBAPvs RVP
odds ratio 0.42 (95% CI 0.25–0.70); P = 0.001
- LBBAP highest P scores
- .931
Further pooled results
Dyssynchrony index and paced QRS duration
- LBBAP achieved the lowest dyssynchrony index and the narrowest paced QRS duration
LVEF at follow-up
- BiVP showed the highest LVEF at follow-up
Procedural success and fluoroscopy duration
- HBP had the lowest procedural success and the longest fluoroscopy duration
Original publication
Is left bundle branch area pacing the optimal pacing strategy for bradyarrhythmia with preserved ejection fraction? A network meta-analysis. Heart Rhythm. Published 19 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →