Heart failure & cardiomyopathies
Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes
Main finding · Incident HFResult — go to the resultHazard ratio 1.83 95% CI 1.53–2.19Authors' conclusion
Isolated NSSTTAs were associated with an increased risk of developing both HFrEF/HFmrEF and HFpEF. These findings challenge the assumption that NSSTTAs are benign and suggest their potential role in HF risk stratification.
Study context
- Population
- REasons for Geographic and Racial Differences in Stroke participants free of heart failure (HF), coronary heart disease (CHD) or major ECG abnormalities at baseline (2003–2007)mean age: 63.1±9.0 years, 60.1% women, 40.0% black
- Participants
- 13,914 participants
- Comparison
- Isolated non-specific ST-T abnormalities (NSSTTAs) and risk of incident HF and its subtypes
- Isolated NSSTTAsn = 3,859
- Outcome
- Incident HF
- Follow-up
- Median 13.5 years (IQR: 7.9-15.6)
Methodological detailsmultivariable Cox proportional hazards models, cause-specific Cox models treating HF subtypes as competing risks
- Multivariable Cox proportional hazards models
- Cause-specific Cox models treating HF subtypes as competing risks
Main finding
As reported in the abstract
Hazard ratio
1.83
95% CI 1.53–2.19
Isolated NSSTTAs
HR 1.83 (95% CI 1.53–2.19)
Further findings
HFrEF/HFmrEF and HF with preserved EF (HFpEF)
| HR (95% CI) | ||
|---|---|---|
| Isolated NSSTTAsHFrEF/HFmrEF; increased risk | 2.19 (1.64–2.93) | |
| Isolated NSSTTAsHFpEF; increased risk | 1.66 (1.23–2.24) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Isolated non-specific electrocardiographic ST-T abnormalities and risk of incident heart failure and its subtypes. Heart. Published 17 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →