Arrhythmias & electrophysiology
Prognostic impact of atrial cardiomyopathy: Long-term follow-up of patients with and without low-voltage areas following atrial fibrillation ablation
Main finding · Irrespective of AF recurrenceResult — go to the resultModified HR 1.73 95% CI 1.13–2.64Authors' conclusion
LVA presence and its extent both were associated with poor long-term composite endpoints of death, heart failure, and stroke, irrespective of AF recurrence or other confounders.
Study context
- Population
- Patients undergoing initial atrial fibrillation (AF) ablation; Low-voltage areas (LVAs) = bipolar peak-to-peak voltage <0.50 mV
- Participants
- 1,488 patients
- Exposure
- Extensive LVAs vs small LVAs vs no LVAs
- No LVAsn = 1,136reference
- Small LVAsn = 250
- Extensive LVAsn = 102
- Outcome
- Composite of:
- Death
- HF
- Stroke
- Follow-up
- Up to 5 years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
Irrespective of AF recurrence
Modified HR
1.73
95% CI 1.13–2.64
P = 0.011
By group
LVA presence vs No LVAs
modified HR 1.73 (95% CI 1.13–2.64); P = 0.011
As reported in the abstract
- P for trend
- <.0001
- Composite endpoints, overall
- 105 of 1488 (7.1%)
Observational data: associations, not effects.
Further findings
- AF recurrence, overall
- 410 (27.6%)
Original publication
Prognostic impact of atrial cardiomyopathy: Long-term follow-up of patients with and without low-voltage areas following atrial fibrillation ablation. Heart Rhythm. Published 28 December 2023. doi:10.
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