Arrhythmias & electrophysiology
Left Atrial Wall Thickness as a Marker of Atrial Substrate in Patients With Atrial Fibrillation
Authors' conclusion
CT-derived LAWT is a promising noninvasive marker of LA substrate.
Study context
- Population
- Adults undergoing index atrial fibrillation (AF) ablation with preprocedure computed tomography (CT) and high-density electroanatomic left atrium (LA) mapping
- Participants
- 77 adults
- Outcome
- Association of CT-derived LAWT with electrical markers of atrial substrate (overall LA and 6 predefined regions)
Main finding
As reported in the abstract
Mean LAWT as independent predictor of substrate markers (multiple linear regression)
Mean bipolar voltage (BV) (β)
1.34; P < 0.001
Conduction velocity (β)
25.63; P = 0.005
% low-voltage points (β)
−30.80; P < 0.001
% conduction slowing/block points (β)
−31.69; P = 0.013
Observational data: associations, not effects.
Further findings
Regional mean left atrial wall thickness (LAWT) vs regional mean BV
- Independent predictor of regional mean BV in all 6 LA segments (anterior/posterior/roof/inferior/septal/lateral)
Regional mean LAWT vs % complex potentials
- Anterior segment (β)
- −5.42; P = 0.033
- Roof segment (β)
- −3.17; P = 0.021
Original publication
Left Atrial Wall Thickness as a Marker of Atrial Substrate in Patients With Atrial Fibrillation. JACC Clin Electrophysiol. Published 20 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it