Left ventricular geometry, brain architecture, and cognition: an observational study
Authors' conclusion
Ventricular geometry emerged as the CV phenotype most strongly associated with brain architecture and cognition.
Study context
- Population
- UK Biobank participants without neurodegenerative diseases or stroke (median age 64 years, 49% female)
- Participants
- 15,519 participants
- Outcome
- Association of CV magnetic resonance imaging (MRI) phenotypes (gSyst, gDiast, gGeom, AoD) with brain MRI phenotypes and cognition
Methodological detailsUK Biobank, multivariable linear regression, exploratory mediation analysis
- UK Biobank
- Multivariable linear regression
- Exploratory mediation analysis
Main finding
As reported in the abstract
gGeom (greater myocardial mass, wall thickness, ventricular volumes) and hippocampal volume, females: β
0.082
0.048–0.117
gGeom and hippocampal volume, males: β
0.039
0.006–0.071
Observational data: associations, not effects.
Original publication
Left ventricular geometry, brain architecture, and cognition: an observational study. Eur Heart J. Published 9 October 2025. doi:10.
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