Heart failure & cardiomyopathies
Left Ventricular Wall Stress and Incident Heart Failure in Elderly Community-Dwelling Individuals
Authors' conclusion
Among community-dwelling elderly individuals, greater LVEDWS is associated with a higher risk for incident HF.
Study context
- Population
- Elderly community-dwelling ARIC participants without prevalent heart failure (HF) who underwent echocardiography 2011–2013156 HF events
- Participants
- 4,601 participants
- Exposure
- Left ventricular (LV) end-systolic and end-diastolic wall stress and incident HF
- Outcome
- Incident hospitalized HF (ICD-9/10 claims)
- Follow-up
- Median 4.6 years
Main finding
As reported in the abstract
Incident HF per 1 kdyne/cm² greater wall stress (adjusted Cox regression) · median 4.6 years
Hazard ratio (95% CI)
LVEDWS (per 1 kdyne/cm²)
1.03(1.01–1.06)
LVESWS (per 1 kdyne/cm²)
1.00(0.99–1.01)
Per 1 kdyne/cm², as printed
Observational data: associations, not effects.
Further findings
Wall stress distribution
- Median LVESWS, kdynes/cm² (25th-75th percentile 39.3-60.1)
- 48.8
- Median LVEDWS, kdynes/cm² (25th-75th percentile 15.8-22.5)
- 18.9
- Correlation of LVESWS and LVEDWS (P < 0.001)
- rho = 0.30
Original publication
Left Ventricular Wall Stress and Incident Heart Failure in Elderly Community-Dwelling Individuals. JACC Adv. Published 13 September 2024. doi:10.
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