Lipoprotein(a) immunoassays and their associations with coronary artery calcification and aortic valve calcification
Authors' conclusion
We demonstrate that these immunoassays provide interchangeable Lp(a) measurements, and that associations with CAC and AVC were near-identical. This provides opportunities to directly compare findings from research done with either immunoassay.
Study context
- Population
- Unselected participants from the Rotterdam Study cohort; Coronary artery calcium (CAC) and aortic valve calcification (AVC) studied in a random subset who underwent cardiac CTunselected participants from the Rotterdam Study cohort
- Participants
- 5,129 participants
- Exposure
- Mass-based vs molar-based immunoturbidimetric Lp assays
- Outcome
- Correlation between Lp(a) concentrations from both immunoassays
Methodological detailscomparison of contemporary immunoturbidimetric assays
- Comparison of contemporary immunoturbidimetric assays
Main finding
As reported in the abstract
Near perfect linear correlation (R2)
98.8%
Observational data: associations, not effects.
Further findings
Natural log-transformed CAC Agatston scores
- Randox standardized linear β
- 0.1003
- Roche standardized linear β
- 0.1004
Natural log-transformed AVC Agatston scores
- Randox standardized linear β
- 0.1525
- Roche standardized linear β
- 0.1539
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lipoprotein(a) immunoassays and their associations with coronary artery calcification and aortic valve calcification. Am Heart J. Published 18 February 2025. doi:10.
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